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Lantus® Is a Basal Insulin With Demonstrated Long-Term CV Safety Data*

*Including CV death, nonfatal MI, nonfatal stroke, revascularization, or hospitalization for heart failure

No statistically significant differences between Lantus® and standard care in the incidence of CV events in the landmark ORIGIN trial1,2

ORIGIN = Outcome Reduction with Initial Glargine Intervention

Study Design

A randomized study of patients with IFG and/or IGT or early T2DM and established CV disease or CV risk at baseline. Patients received either Lantus® (n=6264) titrated to a target FPG of ≤95 mg/dL or standard care (n=6273). Standard care patients remained on their original treatment, if applicable, at randomization. Additional agents could be added as needed per discretion of the investigator. Median follow-up: 6.2 years.1,2


Hypoglycemia Safety Results

aSevere symptomatic hypoglycemia was defined as an event with symptoms consistent with hypoglycemia requiring the assistance of another person and associated with either a BG ≤36 mg/dL or prompt recovery after oral carbohydrate, intravenous glucose, or glucagon administration.


References:

  1. Lantus® Prescribing Information. August 2015.
  2. Gerstein HC, Bosch J, Dagenais GR, Díaz R, Jung H, et al., ORIGIN Trial Investigators. Basal insulin and cardiovascular and other outcomes in dysglycemia. N Engl J Med. 2012 Jul 26;367(4):319-28. doi: 10.1056/NEJMoa1203858. Epub 2012 Jun 11.

Proven HbA1c control

See how Lantus® provides effective, improved glycemic control in diabetes patients.

Lantus® Prescribing Information. August 2015.

Once-daily dosing

Lantus® is a once-daily, long-acting insulin.**

**Lantus® Prescribing Information. August 2015.

Demonstrated long-term CV safety

Lantus® is a basal insulin with demonstrated long-term CV safety data††

††
Including CV death, nonfatal MI, nonfatal stroke, revascularization, or hospitalization for heart failure. No difference was observed between Lantus® and standard of care in overall incidence of CV death, nonfatal MI, or nonfatal stroke. No difference was observed between treatment groups for death of any cause.