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Proven A1C Efficacy1

Lantus® is a once-daily, long-acting insulin that provides 24-hour basal coverage with no pronounced peak.1 Lantus® can provide effective glycemic control in diabetes patients as part of an overall diabetes treatment plan, which includes diet, exercise, and other diabetes medications.

In type 2 diabetes cases, basal insulin therapy is typically initiated after lifestyle changes and OAD(s) fail to yield the glycemic goal set by a patient's healthcare professional.2 Adding Lantus® to an oral regimen has been shown to be effective at improving and sustaining glycemic control.2,3

The clinical efficacy of Lantus® has been evaluated in patients with type 1 and type 2 diabetes mellitus in several large, randomized, multicenter trials.

How Lantus® Works

Video Transcript

Frame 1

Product Description

Frame 2

SUPER: Product Description

Voiceover: All known insulins are composed of two polypeptide chains that are linked to one another by disulfide bonds. Lantus® differs from human insulin in that the physiochemical properties have been modified.

Frame 3

Voiceover: The amino acid asparagine at the position A21 is replaced by glycine and two arginines are added to the C terminus of the B chain.

Frame 4

Voiceover: The effect of these changes is to shift the isoelectric point, producing a solution that is completely soluble at pH 4.

Frame 5

Voiceover: When injected into the subcutaneous tissue, which has a physiologic pH of 7.4, the acidic solution is neutralized.

Frame 6

Voiceover: This leads to the formation of micro precipitates, from which small amounts of Lantus® are slowly released. Insulin crystals exist in hexamer form.

Frame 7

Voiceover: When micro precipitates develop, the hexamer is subdivided into three dimers, each of which divides into two monomers.

Frame 8

Voiceover: This slow dissolution of free hexamers results in a relatively constant concentration time profile over 24 hours with no pronounced peak. This profile is what allows Lantus® to be dosed once daily as a patient's basal insulin.

Frame 9

Lantus® (insulin glargine injection) 100 Units/mL


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  1. Lantus® Prescribing Information. February 2015.
  2. Gerstein HC, Yale J-F, Harris SB, et al. Diabetic Med. 2006;23(7):736-742.
  3. Riddle MC, Rosenstock J, Gerich J, on behalf of the Insulin Glargine 4002 Study Investigators. Diabetes Care. 2003;26:3080-3086.

Proven HbA1c control

See how Lantus® provides effective, improved glycemic control in diabetes patients.

Lantus® Prescribing Information. February 2015.

Once-daily dosing

Lantus® is a once-daily, long-acting insulin.**

**Lantus® Prescribing Information. February 2015.

Demonstrated long-term CV safety

Lantus® is a basal insulin with demonstrated long-term CV safety data††

Including CV death, nonfatal MI, nonfatal stroke, revascularization, or hospitalization for heart failure. No difference was observed between Lantus® and standard of care in overall incidence of CV death, nonfatal MI, or nonfatal stroke. No difference was observed between treatment groups for death of any cause.